UV spectrophotometric method for determination of phenacetin in biological specimens
Identifieur interne : 003A90 ( Main/Exploration ); précédent : 003A89; suivant : 003A91UV spectrophotometric method for determination of phenacetin in biological specimens
Auteurs : Jack E. Wallace [États-Unis] ; John D. Biggs [États-Unis] ; Horace E. Hamilton [États-Unis] ; Lloyd L. Foster [États-Unis] ; Kenneth Blum [États-Unis]Source :
- Journal of Pharmaceutical Sciences [ 0022-3549 ] ; 1973-04.
English descriptors
- Teeft :
- Absorbance, Aerospace medicine, Axelrod, Biological specimens, Body weight, Cobaltic, Cobaltic oxide, Ether, Hydroxide, Maximum absorbance, Naoh, Oxidized, Paminophenol, Pharmacological agents, Phenacetin, Phenacetin product, Primary metabolite, Sodium chloride, Sodium hydroxide, Sodium hydroxide solution, Solvent layer, Spectrophotometric, Spectrophotometric method, Urine, Usaf school.
Abstract
A UV spectrophotometric procedure for determining phenacetin in biological specimens is described. The drug is extracted from biological material by ether and oxidized to a quinone product by cobaltic oxide. The primary metabolite of phenacetin, N‐acetyl‐p‐aminophenol, is assayed by providing a salting‐out step in the extraction process. Better than 90% of phenacetin added to urine and serum specimens in vitro at concentrations of 5–50 mcg./ml. was recovered. From homogenized tissue, 83% of added phenacetin was recovered.
Url:
DOI: 10.1002/jps.2600620411
Affiliations:
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Foster</name></author><author><name sortKey="Blum, Kenneth" sort="Blum, Kenneth" uniqKey="Blum K" first="Kenneth" last="Blum">Kenneth Blum</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B84F057C704B92267D7F13AC148CC9326E429575</idno><date when="1973" year="1973">1973</date><idno type="doi">10.1002/jps.2600620411</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-S4DQPVFB-B/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002B96</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002B96</idno><idno type="wicri:Area/Istex/Curation">002B96</idno><idno type="wicri:Area/Istex/Checkpoint">002830</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002830</idno><idno type="wicri:doubleKey">0022-3549:1973:Wallace J:uv:spectrophotometric:method</idno><idno type="wicri:Area/Main/Merge">003B70</idno><idno type="wicri:Area/Main/Curation">003A90</idno><idno type="wicri:Area/Main/Exploration">003A90</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">UV spectrophotometric method for determination of phenacetin in biological specimens</title><author><name sortKey="Wallace, Jack E" sort="Wallace, Jack E" uniqKey="Wallace J" first="Jack E." last="Wallace">Jack E. Wallace</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Pathology, University of Texas Medical School at San Antonio, San Antonio</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Correspondence address: Department of Pathology, University of Texas Medical School at San Antonio, San Antonio</wicri:cityArea></affiliation></author><author><name sortKey="Biggs, John D" sort="Biggs, John D" uniqKey="Biggs J" first="John D." last="Biggs">John D. Biggs</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Forensic Toxicology Branch, USAF School of Aerospace Medicine, Aerospace Medical Division, Brooks Air Force Base</wicri:cityArea></affiliation></author><author><name sortKey="Hamilton, Horace E" sort="Hamilton, Horace E" uniqKey="Hamilton H" first="Horace E." last="Hamilton">Horace E. Hamilton</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Forensic Toxicology Branch, USAF School of Aerospace Medicine, Aerospace Medical Division, Brooks Air Force Base</wicri:cityArea></affiliation></author><author><name sortKey="Foster, Lloyd L" sort="Foster, Lloyd L" uniqKey="Foster L" first="Lloyd L." last="Foster">Lloyd L. Foster</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Forensic Toxicology Branch, USAF School of Aerospace Medicine, Aerospace Medical Division, Brooks Air Force Base</wicri:cityArea></affiliation></author><author><name sortKey="Blum, Kenneth" sort="Blum, Kenneth" uniqKey="Blum K" first="Kenneth" last="Blum">Kenneth Blum</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Pharmacology, University of Texas Medical School at San Antonio, San Antonio</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Pharmaceutical Sciences</title><title level="j" type="alt">JOURNAL OF PHARMACEUTICAL SCIENCES</title><idno type="ISSN">0022-3549</idno><idno type="eISSN">1520-6017</idno><imprint><biblScope unit="vol">62</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="599">599</biblScope><biblScope unit="page" to="601">601</biblScope><biblScope unit="page-count">3</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Washington</pubPlace><date type="published" when="1973-04">1973-04</date></imprint><idno type="ISSN">0022-3549</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3549</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Absorbance</term><term>Aerospace medicine</term><term>Axelrod</term><term>Biological specimens</term><term>Body weight</term><term>Cobaltic</term><term>Cobaltic oxide</term><term>Ether</term><term>Hydroxide</term><term>Maximum absorbance</term><term>Naoh</term><term>Oxidized</term><term>Paminophenol</term><term>Pharmacological agents</term><term>Phenacetin</term><term>Phenacetin product</term><term>Primary metabolite</term><term>Sodium chloride</term><term>Sodium hydroxide</term><term>Sodium hydroxide solution</term><term>Solvent layer</term><term>Spectrophotometric</term><term>Spectrophotometric method</term><term>Urine</term><term>Usaf school</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A UV spectrophotometric procedure for determining phenacetin in biological specimens is described. The drug is extracted from biological material by ether and oxidized to a quinone product by cobaltic oxide. The primary metabolite of phenacetin, N‐acetyl‐p‐aminophenol, is assayed by providing a salting‐out step in the extraction process. Better than 90% of phenacetin added to urine and serum specimens in vitro at concentrations of 5–50 mcg./ml. was recovered. From homogenized tissue, 83% of added phenacetin was recovered.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Wallace, Jack E" sort="Wallace, Jack E" uniqKey="Wallace J" first="Jack E." last="Wallace">Jack E. Wallace</name></region><name sortKey="Biggs, John D" sort="Biggs, John D" uniqKey="Biggs J" first="John D." last="Biggs">John D. Biggs</name><name sortKey="Blum, Kenneth" sort="Blum, Kenneth" uniqKey="Blum K" first="Kenneth" last="Blum">Kenneth Blum</name><name sortKey="Foster, Lloyd L" sort="Foster, Lloyd L" uniqKey="Foster L" first="Lloyd L." last="Foster">Lloyd L. Foster</name><name sortKey="Hamilton, Horace E" sort="Hamilton, Horace E" uniqKey="Hamilton H" first="Horace E." last="Hamilton">Horace E. Hamilton</name><name sortKey="Wallace, Jack E" sort="Wallace, Jack E" uniqKey="Wallace J" first="Jack E." last="Wallace">Jack E. Wallace</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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